Connexins and Disease
نویسندگان
چکیده
منابع مشابه
Connexins and cell signaling in development and disease.
Gap junctions contain hydrophilic membrane channels that allow direct communication between neighboring cells through the diffusion of ions, metabolites, and small cell signaling molecules. They are made up of a hexameric array of polypeptides encoded by the connexin multi-gene family. Cell-cell communication mediated by connexins is crucial to various cellular functions, including the regulati...
متن کاملLife cycle of connexins in health and disease.
Evaluation of the human genome suggests that all members of the connexin family of gap-junction proteins have now been successfully identified. This large and diverse family of proteins facilitates a number of vital cellular functions coupled with their roles, which range from the intercellular propagation of electrical signals to the selective intercellular passage of small regulatory molecule...
متن کاملConnexins and the kidney.
Connexins (Cxs) are widely-expressed proteins that form gap junctions in most organs, including the kidney. In the renal vasculature, Cx37, Cx40, Cx43, and Cx45 are expressed, with predominant expression of Cx40 in the endothelial cells and Cx45 in the vascular smooth muscle cells. In the tubules, there is morphological evidence for the presence of gap junction plaques only in the proximal tubu...
متن کاملConnexins and Diabetes
Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called "connexins." In this paper, we discuss current knowledge about connexins in diabetes. We also discuss mechanisms ...
متن کاملWhich connexins connect?
Electrical signaling via gap junctions modulates vascular function via 2 physiologically interrelated mechanisms, namely dilations/constrictions that propagate longitudinally along the vessel wall,1–4 and the EDHF phenomenon, in which relaxation is facilitated by the transmission of endothelial hyperpolarization to smooth muscle via a radial myoendothelial pathway.5 Gap junctions are composed f...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2017
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a029348